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SAM is the body's primary methyl donor for hundreds of methylation reactions (DNA methylation, protein methylation, neurotransmitter synthesis, etc.)
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10.1038/s41586-019-1227-y 375 MartinD
[13] In my opinion, methylation issues and the MTHFR gene variation can contribute to some of the symptoms commonly attributed to, or associated with, hypothyroidism
These studies indicate that gene silencing correlates with DNA methylation, consistent with data from our study, which investigated vitamin D metabolizing gene expression