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On average people regain about 60% of the weight they lost within a year of stopping, though roughly a quarter of the loss is retained

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A 2.6% reduction in hip bone mineral density and a 2.1% reduction at the lumbar spine in 52 weeks (Hansen et al., 2024), combined with up to 10.9% lean mass loss over 72 weeks (Look et al., 2025), means that patients on GLP-1 therapy need a comprehensive musculoskeletal protection plan from day one

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These results may inform research into psychiatric safety and potential repurposing opportunities for GLP-1RAs, especially in people with mental health disorders, but randomized clinical trials are needed to determine whether the genetic associations translate into treatment benefits

Of note, our findings are in line with two small studies showing the prognostic impact of serum histidine in patients with cancer 30,77