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It is quite different from the intermittent hypoxic conditions associated with some diseases, such as obstructive sleep apnea syndrome

Among those with fatty liver, liver fat fell 51%

On phase: up to 3 months of active dosing, following the Month 1 to Month 3 titration

Injections are particularly appropriate for those with: Pernicious anaemia, an autoimmune condition affecting B12 absorption Conditions affecting the stomach or small intestine, such as Crohns disease or coeliac disease Those who have had gastric surgery or bariatric procedures Strict vegans and vegetarians not meeting their B12 needs through food or oral supplements For those who can absorb B12 normally, oral supplements are generally an effective and well-evidenced alternative to injections

others (like a tri-agonist by Pfizer) are in mid-stage trials

Almost all have issues- side effects weak results weight regain GLP-1 drugs do not just suppress cravings