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The company announced yesterday that it has officially begun enrolling participants in a Phase 2 trial of pemvidutide, its GLP-1 and glucagon dual receptor agonist, to evaluate the drug in people with Alcohol Use Disorder, or AUD

SPI-1005 operates as an oral organoselenium mimic of the endogenous antioxidant enzyme glutathione peroxidase 1 (GPx1) , reducing hydrogen peroxide accumulation, protecting stria vascularis integrity, and supporting inner ear cell signaling during oxidative strain

However, both require ongoing monitoring and lifestyle support

Without regulatory oversight, product purity, accurate dosing, and sterility cannot be guaranteed factors that significantly increase the potential for harm

Biological Psychiatry, 53(3), 193-203

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