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7.2 Comparing with the novel metabolic target drugs As the FXR-activating function of GLP-1RAs, FXR agonists may have the same effect as GLP-1RAs (Errafii et al., 2022)
Wegovy also contains semaglutide but is approved for weight loss rather than type 2 diabetes
According to NICE guidance, GLP-1 receptor agonists for type 2 diabetes (NG28) are recommended when other treatments have not achieved adequate glycaemic control
The overarching material developed and investigated comprises AngIV-based compounds, designed to overcome the limitations of native peptides like AngIV, which suffer from poor metabolic stability and inability to cross the BBB due to their size and hydrophilicity
Diabetes Care 37:2430
TGA-approved Australia 2024
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