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The WHO defined a biomarker as any substance, structure, or process that can be measured in the body or its products and influence or predict the incidence of outcome or disease (WHO 2001)

Cycle Guidelines (community-derived from compound-level data) Approach Pre-blended daily Loading Maintenance 0.52.0 mg total blend daily Total cycle 612 weeks Common context Convenience-first, steady exposure Approach Separate vials standard Loading Weeks 14 Maintenance Weeks 58 Total cycle 812 weeks Common context Loading-then-taper for injury planning Approach Separate vials extended Loading Weeks 14 Maintenance Weeks 512 Total cycle 12 weeks Common context Slower-healing tissue research planning These are research-planning structures, not treatment plans

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