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In Ageing Despite its ability to promote longevity, NRF2 is ironically suppressed during aginga time when the organisms might most need its function

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Acetyl L-carnitine (ALC) is a special form of L-carnitine, an amino acid that the body uses to turn fat into energy

Although these mice initially exhibit normal cardiac function, they progressively develop left ventricular dilation, reduced fractional shortening, disorganized sarcomeres, and damaged mitochondria with aging, highlighting the essential role of sustained autophagy in maintaining structural integrity and contractile function over time