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A 2025 Bayesian network meta-analysis of 48 RCTs covering 27,729 participants compared GI adverse events across the major GLP-1 RAs.[1] Tirzepatide showed the highest risk of nausea and diarrhea among the agents studied

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The oral pathway mediates rapid neural transmission, while the intestinal pathway mediates slower hormonal responses, both converging on the GBA (57, 58)

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