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As GLP-1 RAs are contraindicated for people with gastrointestinal disease, pancreatitis, or a family history of mutations in multiple endocrine neoplasia type 2/medullary thyroid carcinoma (MEN2/MTC), SGLT2i is the preferred treatment for these patients groups

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Niacinamide and tirzepatide Niacinamide (vitamin B3) with tirzepatide is another combination being explored

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It has gained attention for its potential roles in tissue repair, anti-inflammatory action, and neuroregeneration