J Hum Genet 55:565570
In addition, cancer cells chronically exposed to an acidic pH reveal a downregulation of the mitochondrial ACC2 isoform, the enzyme that regulates CPT1 activity by malonyl-CoA synthesis
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Furthermore, in an ID state, the iron transport and storage functions of M2 macrophages are altered, resulting in reduced iron availability within the tumor microenvironment, further exacerbating immunosuppression and supporting tumor progression
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Hyperammonemia (a determining factor in its pathogenesis) leads to brain dysfunction associated with neuropsychiatric and neurologic complications