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Repeated compression of the dosing interval increases your average drug exposure beyond what was prescribed, elevates side effect risk, and disrupts the steady-state pharmacokinetics that your body has adapted to

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If you consistently feel worse on injection days, schedule rest days or light activity (walking only) for those days

The calculation depends on your final concentration

According to FDA prescribing information, these effects include nausea (12-30%), diarrhea (7-23%), vomiting (2-11%), constipation (5-17%), and abdominal pain (4-10%), with rates varying by dose and indication

Ranimation 2004, 13: 324-333