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These recommendations do not represent FDA approval, and any addition to the list still requires public rulemaking
I was surprised by the number of steps included and how involved it ended up being
Hepatic enzymes (cytochrome P450 oxidases, glucuronosyltransferases) metabolise and conjugate the compound, reducing the amount that reaches target tissues
Reduced Inflammation Optimal B12 levels may help modulate inflammatory responses: Supports balanced immune function Helps regulate cellular repair mechanisms May reduce inflammatory markers in some individuals Supports overall cellular health This anti-inflammatory effect can contribute to improvements in various inflammatory conditions
A review of B12 studies for neuropathic pain found positive results
A batch that is 99% pure but incorrectly synthesized will show high HPLC purity while delivering zero biological activity
