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Leptin is a cytokine of the long-chain helical cytokine family, containing interleukin-6, granulocyte colony-stimulating factor and growth hormone

Many of the mechanisms have been elucidated by the Jaeschke group in Kansas [18,36,37]

Each mediator balances tissue O 2 supply by altering vessel tone and diameter and can contribute to a long-term remodeling of vascular structure, subsequently governing organ perfusion [52]

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