Most side effects are mild, like nausea or constipation, and usually decrease as treatment continues
The greater magnitudes of bodyweight reduction seen in this trial, as well as the improvements in cardiovascular risk factors and glucose control, can have beneficial effects on health goals in clinical practice. In the STEP UP T2D trial, a higher semaglutide dose resulted in an average bodyweight reduction of 13.2%, compared to 10.4% for the standard dose and 3.9% for the placebo
Follow JAMA+ Trials to get curated access to the best of the JAMA Networks trial research, commentaries, and educational resources
H.BaileyC
Personal preference, injection frequency tolerance, and availability typically drive the final selection
UV radiation, especially UVA and UVB, triggers ROS production in melanocytes, leading to oxidative DNA damage that can initiate oncogenic mutations