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8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs

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95% CI, 1.02-2.04), but this study did not find an association between plasma concentrations of vitamin B 12 and breast cancer (55)

B12 injections are an effective way to get the needed vitamin

How long results hold depends on factors like condition severity, lifestyle habits, dosage, and whether the full protocol was completed