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Many patients using these medications notice small air bubbles within the pen cartridge and understandably worry about their significance

(There is a method, advocated by some US doctors, in which phenobarbitone, a long-acting barbiturate, is substituted for a benzodiazepine and then slowly withdrawn, but this method has no particular advantages over tapering directly from a long-acting benzodiazepine)

However, there are some differences between these two drugs that you should know about

Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy

The shared consideration is delayed gastric emptying, which is why TSH monitoring after starting any of them makes sense

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