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The trial included a 24-week extension period at doses of 9 or 12 mg for about 500 adults with a BMI of 35 or greater, which is classified as severe obesity
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Strikingly, our GSEA analysis also showed that ablation of Gclc in FoB displayed a similar increase in mTORC1 signaling genes compared to Gclc fl/fl FoB and Gclc fl/fl MZB (Fig
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dose reductions of these medications may be needed when initiating GLP-1 therapy
