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When the barrier between the gut and the bloodstream weakens, bacterial fragments and other compounds can cross where they do not belong, and the immune system responds

These agents mimic the biological action of the native incretin hormone GLP-1 but are structurally modified to resist degradation by the enzyme dipeptidyl peptidase 4 (DPP-4), thereby extending their half-life and duration of action (Zheng et al., 2024

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Improved sleep quality is frequently one of the earliest benefits, with patients reporting deeper, more restful REM cycles

PMID: 31861912