oral semaglutide phase 3 A new class of GLP-1 that works differently than oral just got one step closer to FDA approval. Eli Lilly released new data on orforglipron. Swipe to learn Avi Roy on X: "https://t.co/4QMRc5CdTV"

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Increased bioavailability: Sublingual delivery can enhance the bioavailability and thus the effectiveness of semaglutide by avoiding the first-pass metabolism in the liver, which can degrade the medication when taken orally

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These considerations are especially important, as CMS has opted not to require coverage for obesity treatments in Medicare for 2026, leaving commercial payers to independently navigate the issue

They all have a clear physiological explanation

Change in Body Weight (%) from Baseline to Week 68 (Study 6 in East-Asian Patients) with WEGOVY Injection Observed values for patients completing each scheduled visit and estimates with multiple imputations from retrieved dropouts (RD-MI)