Acknowledgments We would like to acknowledge the children and parents who participated in this clinical trial
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A 2024 review in Circulation summarized the skeletal-muscle data across multiple GLP-1 trials and concluded that the observed changes appear adaptive rather than pathological. In March 2026, Langer and colleagues published a direct test of the muscle question in Cell Reports Medicine, albeit in mice
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According to the USDA, Vitamin B12 deficiency is believed to be one of the most common nutrient deficiencies in the world, especially among people taking stomach acid-altering medications and antibiotics frequently, along with the elderly and sometimes vegetarians/vegans