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In vivo, ouabain-treated mice harbored a decrease of senescent cells in an OIS model, a whole-body irradiation model as well as in aged mice
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This is significantly longer than the few seconds of endogenous -MSH, but remains short compared to long-acting analogs such as subcutaneous afamelanotide implant (release over 60 days)
Off-label use for general visceral fat reduction and anti-aging is common in clinical practice and legally permissible when prescribed by a licensed provider
ARC, arcuate nucleus of the hypothalamus
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