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It has also shown beneficial effects in rats with various gastrointestinal anastomoses, even when impaired with the application of NSAIDs, cysteamine, large bowel resection, and other conditions

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Figure2

This gradual escalation prevents overwhelming side effects like flushing, nausea, or headaches that occur when starting at high doses, allows the pituitary to adapt to regular stimulation improving long-term response, and provides opportunity to identify minimal effective dose avoiding unnecessary higher dosing and associated costs