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Our plan for the solution phase synthesis of peptide 2 was based on the [(2+2)+1+1] scheme for assembly of the linear hexapeptide backbone using benzyloxycarbonyl (Z) group as the temporary protection for amino acids N -termini (Scheme 1)
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Sermorelin is a 29-amino acid GHRH fragment without protective substitutions, giving it a very short half-life of about 7 to 10 minutes
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