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Tirzepatide does not impair exercise performance, but reduced caloric intake can affect energy levels during workouts
17 : 132136 Krsmanovic LZ, Virmani MA, Stojilkovic SS, Catt KJ
Relying solely on the drug without addressing nutrition or activity levels often leads to muscle loss rather than just fat loss, or weight regain if the medication is stopped
Participants who made it past week 12 without discontinuing had an 87% chance of achieving at least 15% weight loss by week 48
The newer Wegovy 7.2 mg dose achieves 20.7%, a difference of around 1 to 2 percentage points
Both tirzepatide and certain SSRIs (particularly sertraline) can cause nausea, so your provider may suggest staggering the start of each medication to isolate which one causes any GI discomfort
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