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SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103
Large-scale human trials evaluating lifespan, disease prevention, or long-term aging outcomes do not currently exist
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hES-MSCs were also cultured at densities of 2, 3, 4, and 5 10 3 cells/cm 2 followed by functional analysis for oxidant resistance at different culture conditions
Toxicol Mech Methods 24:703712
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