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Administration of anthracyclines results in acute, early-onset, and delayed-onset cardiotoxicity, and the risk of developing heart failure increases as the cumulative doses increase, but in some cases, it can occur more than two decades after medication therapy has been completed

Without it, the body cannot effectively cross-link the amino acids into stable collagen fibers

It can induce high-output heart failure, and this effect seems to be dose-related but can occur days to years after therapy

Some GSTs behave as glutathione peroxidases, and others possess non-enzymatic functions regulating a number of cellular processes that contribute to the intrinsic ability of cells to survive genotoxic, metabolic and oxidative stress