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Nau The primary outcomes were rates of hypertensive disorders of pregnancy, gestational diabetes, preterm birth and cesarean delivery between the two cohorts

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suggested that renal tubules are not sensitized to necroptosis by loss of FADD or caspase-8, and the RIPK1 inhibitor nec-1 does not protect freshly isolated tubules from hypoxic injury, while ferroptosis directly causes synchronized necrosis of renal tubules in models of IRI-AKI [37]

This earlier study was uncontrolled, however, but justified the subsequent controlled trial