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( a ) Schematic visualization of the experimental setup

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5-Amino-1MQ inhibits NNMT

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Preclinical models demonstrate that region-specific elevations of central KYNA highlight a functional trade-off: while KYNA is often considered neuroprotective due to its antagonism of glutamatergic receptors, its broad receptor profile also allows it to inhibit 7nAChRs, which are essential for prefrontal cortical processing and mood regulation