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The compound failed its Phase IIb obesity endpoint in 2007, and Metabolic Pharmaceuticals terminated clinical development the same year

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Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

Senescence-Associated Secretory Phenotype (SASP) and Senotherapy in Aging

Serious risks include pancreatitis and a potential risk of thyroid C-cell tumors