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Nicholls SJ, Tofe S, le Roux CW, DAlessio DA, Wiese RJ, Pavo I, Brown K, Weerakkody GJ, Zeytinoglu M, Romera IC

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MELAS is not the result of a single gene defect and as such represents a constellation of related disorders that can result from defects in several of the mitochondrial genome encoded proteins of complex I