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Published data suggests ipamorelin may increase IGF-1 levels by 15-30% in responder populations, while sermorelin studies report variable outcomes ranging from modest to moderate GH elevation depending on dosing, frequency, and baseline age
And variable absorption from the oral route might create inconsistent blood levels that produce more gastrointestinal disturbance than the steady pharmacokinetic profile of weekly injections
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A recent doubleblind, randomized, placebocontrolled study comparing liraglutide, supervised exercise, their combination, and placebo over one yearfollowed by one year without treatmentoffers additional insight [142]
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