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The Physiology of Glucagon-like Peptide 1
The review covered GLP-1s roles in controlling islet function, appetite, inflammation, and cardiovascular pathophysiology, and made a critical mechanistic distinction: native GLP-1 acts primarily via paracrine and neural mechanisms (given its 12 minute plasma half-life), whereas GLP-1RA drugs with extended half-lives act systemically on GLP-1R populations inaccessible to the native peptide
Fat metabolism / lipolysis The primary draw: studied in preclinical models for how the hGH 176-191 fragment may stimulate fat breakdown
Wang S, et al
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7 Molecular dynamics (MD) simulations of compound 2-bound active GLP-1R
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