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VDAC opening mediates the entry of most metabolites into mitochondria, promoting mitochondrial oxidative phosphorylation and ROS production, and ultimately leading to mitochondrial dysfunction

We would like to thank the Core Science and Technology Research Facility of the University of Cadiz for the use of core infrastructure

Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea

Furthermore, GSTP1-1 has also been shown to bind and inhibit tumor necrosis factor receptor-associated factor 2 (TRAF2), an upstream activator of JNK, thus blocking the MAPK/JNK signaling cascade at multiple levels 29

[PMID: 3074360] PubMed record related to this compound for laboratory literature review