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Concurrent application with highly acidic or strongly chelating topical agents-such as concentrated ascorbic-acid serums-may reduce the activity of one or both products because copper ions can catalyze oxidation reactions

As the primary barrier to environmental and metabolic stress, the skin is susceptible to oxidative damage

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74,75,76 Similarly, extracellular sequestosome 1 (SQSTM1, an autophagy receptor) 77 has been shown to enhance ferroptotic susceptibility by upregulating acyl-CoA synthetase long-chain family member 4 (ACSL4), thereby promoting pancreatic necrosis

doi: 10.1007/s00330-023-10035-1 172 PengX.LiC.YuW.LiuS.CongY.FanG.et al