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Patients with periodontitis exhibit persistent dysbiosis of the gut microbiota and distinct serum metabolome

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Its primary mechanisms involve tissue healing through enhanced angiogenesis, growth factor modulation, and nitric oxide system interaction

Since oxidative stress increases the heterogeneity of the RBCs population, the hematological parameter RDW might be preferable for detection and analysis of damaging levels of oxidizing agents and deterioration of microcirculation than MCV

In these patients, maintenance dosing is strongly preferred over complete discontinuation