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These medications improve several metabolic health markers: Lower blood pressure Improved cholesterol profiles Reduced inflammation markers 8 Modest 5-7% weight loss significantly reduces type 2 diabetes risk 6

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There are some limitations acknowledged to this study, including a relatively low sample size (owing to the rarity of IIH) and a short follow-up period, partially mitigated by the standardized data collection and thorough quality control applied within the VIIH

The largest trial of ERAs, SONAR, including 2648 participants with type 2 diabetes and proteinuric CKD, demonstrated that atrasentan on top of RAS inhibition significantly lowered the risk of a doubling of serum creatinine or ESKD compared with placebo by 35% [75]