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In Phase 3 TRIUMPH-4, about 20.9% of participants at the highest dose reported dysesthesia, which means unusual skin sensitivity or tingling

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While the kidneys contain the primary 1-alpha-hydroxylase activity for endocrine functions, many tissues possess local conversion capability

By age 60, that number drops to roughly 80 ng/mL a decline that parallels the measurable drop-offs in skin repair and regenerative capacity that come with age