Effects of long-term administration of LAC on rats increased dopamine production in the marginal division of the rat cortex and protective effects on acute stress exposure (96)
Ringseis R et al
Um, but, there is Russian Roulette and, uh, Russian Roulette is taking pills that have a substantial and to some extent not fully quantified risk when the benefits are cosmetic

When to contact your GP or diabetes specialist nurse: If you've been taking expired Rybelsus and notice worsening blood glucose control If you experience unexplained symptoms such as persistent thirst, increased urination, or fatigue If you're unable to obtain a fresh supply of your medication For advice on alternative diabetes management strategies if Rybelsus is temporarily unavailable Seek urgent medical advice (call NHS 111) or emergency care (999) if you experience: Severe dehydration (extreme thirst, dry mouth, little or no urination) Confusion or drowsiness Rapid breathing Severe abdominal pain or persistent vomiting Very high blood glucose levels that don't respond to usual treatment These could be signs of severe hyperglycaemia or hyperosmolar hyperglycaemic state (HHS), which requires immediate medical attention

Studied context Two registered trials and three small uncontrolled human reports The controlled human record is a Phase 1 safety/PK trial with no posted results and a Phase 2 hamstring trial still recruiting
A practical way to think about it on a GLP-1: aim for steady, consistent fluid throughout the day rather than chugging a large amount at once, and let the color of your urine guide you