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The medications work through several complementary mechanisms: Appetite suppression : Acting on receptors in the hypothalamus to reduce hunger signals and increase satiety Delayed gastric emptying : Slowing the rate at which food leaves the stomach, prolonging feelings of fullness Enhanced insulin secretion : Stimulating glucose-dependent insulin release from pancreatic beta cells Reduced glucagon secretion : Decreasing the hormone that raises blood glucose levels Clinical efficacy for weight loss has been demonstrated in clinical trials
Many healthcare professionals are concerned that those with restrictive eating disorders should not be on appetite-suppressant drugs, says Pamela Keel, a psychologist and eating disorder expert at Florida State University
Treatment with GLP-1RAs can provide supraphysiologic and sustained stimulation of the GLP-1 receptor
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The initial water weight gain 3 to 5 pounds in the first two weeks is intramuscular, not subcutaneous fat, and does not affect appearance meaningfully
