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Optical profilometry analyses show reductions in wrinkle depth of approximately 14 to 28% depending on the studies and the areas treated

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Moreover, knockdown of HMGB1 or S1R, as well as overexpression of Sirt6, alleviates diabetic nephropathy by regulating the NRF2 pathway, indicating the potential of NRF2 as a research target [61, 128, 129]