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[3] OLeary VB, Parle-McDermott A, Molloy AM, et al

However, under starvation cells increase production of mitochondrial-derived hydrogen peroxide, which has been shown to be partly dependent on the activation of class III PI3K (Scherz-Shouval and Elazar, 2007)

Boosting NAD+ has been shown to extend the lifespan of diverse organisms 2 NAD metabolism: Implications in aging and longevity | Yaku et al

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Mater 33 (20), 2100599