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27 Evidence From Clinical Trials The clinical evidence supporting the use of GLP-1RAs in HF has primarily emerged from cardiovascular outcome trials (CVOTs) in patients with T2D and dedicated HF trials ( Table 1 )

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The program is structured around a maintenance philosophy, not a fixed end date

8% on placebo) and with low risk of symptomatic or confirmed hypoglycemia (5.5% vs

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These observations were corroborated by single-cell calcium imaging studies in slices of arcuate nuclei, demonstrating that GLP-1MK-801 inhibits the NMDA-induced intracellular calcium surge relative to GLP-1 alone (Extended Data Fig