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-Tocopherol is rapidly lost from the circulation, and more metabolites of -tocopherol are excreted in urine compared to -tocopherol, suggesting less -tocopherol is needed for use by the body (1)

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Glutathione is composed of the amino acids L-cysteine, L-glutamic acid, and glycine

At the same time, side effects like nausea and vomiting are common, which may limit tolerance for some patients

After being transported outside the cells, GSH is degraded by eukaryotic membrane-bound GGT which removes the -glutamyl moiety 28

Gallbladder issues, like gallstones, are rare but possible