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As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

Despite promising preliminary findings, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses

PMID: 19075619

PMN-MDSCs, on the other hand, facilitate metastasis by restoring the epithelial-to-mesenchymal transition and inducing CSC properties [25]

brain fog) in depression patients

Are anti-inflammatory peptides safe