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Its main efficacy goal was not met

AOD9604 and Cartilage Biology Research In a collagenase-induced knee osteoarthritis rabbit model, intra-articular injection of AOD9604 significantly enhanced cartilage regeneration compared to saline controls, with combined AOD9604 and hyaluronic acid injections proving more effective than either treatment alone producing superior morphological and histopathological scores and a significantly shorter lameness period in the AOD9604 + HA group

In major European markets Germany, France, the U.K., Scandinavia biosimilar adoption for reference products like adalimumab, infliximab, and etanercept has been rapid and deep, with some reference products losing 80-90% of their market share within 12-18 months of biosimilar entry

Vitamin D deficiency in Europe: pandemic

In some cases, patients go into metabolic acidosis and require hospitalization

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