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Karl Nadolsky, endocrinologist and diplomate at the American Board of Obesity Medicine

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Critics argue that overemphasis on pharmaceutical interventions could detract from holistic lifestyle modifications, which are crucial for sustainable health

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8 Concerningly, lifestyle improvements are often difficult to sustain, underscoring the potential benefits of early initiation and background therapy with GLP-1RA due to its benefits on metabolic disorders (Table 3) and chronic liver disease

Aoyama E, Watari I, Podyma-Inoue KA, Yanagishita M, Ono T (2014) Expression of glucagon-like peptide-1 receptor and glucose-dependent insulinotropic polypeptide receptor is regulated by the glucose concentration in mouse osteoblastic MC3T3-E1 cells