Cereb Cortex
With over a decade of post-marketing surveillance data, the long-term risk profile is better characterized than any other GLP-1 agonist
No weight-loss intervention however promising in early trials should be pursued without qualified medical guidance and oversight
Its non-selectivity, considered a clinical drawback, is a scientific advantage: it allows for the isolation of the relative contributions of each MCR subtype using selective antagonism protocols (HS024, JNJ-10229570, MCL-0129)
A secondary analysis also revealed preserved or improved physical function, with a significant reduction in the prevalence of slow gait speed ( 0.35), including IHTG ( p = 0.88 for PCGrimAge, p = 0.36 for PCDNAmTL), suggesting the IHTG association may be marker-specific to DunedinPACE in this pilot analysis (Fig
By integrating insights from ophthalmology, endocrinology, and cardiovascular medicine, we aim to guide clinical practice and research to reduce the global burden of DR, preserve vision, and enhance quality of life for diabetic patients