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Although the rectal route bypasses the respiratory tract, systemic effects could theoretically still occur, and patients with asthma should be monitored closely

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doi: 10.3390/jcm9072095 290 WangS.LiZ.WangX.ZhangS.GaoP.ShiZ

If someone has had an adverse reaction to echinacea ( Echinacea spp.) or chamomile ( Matricaria chamomilla ), for example, they may be sensitive to calendula as well

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Dark, leafy greens