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In 1 patient, increase in pancreatic lipase levels was observed, which resolved spontaneously 6 months after treatment initiation
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A patient with favorable GLP1R variants may achieve strong semaglutide response at lower doses, while someone with different genetic markers might benefit from combination therapy or higher dosing strategies
This is mediated through the activation of the caspase cascade [247]
However, this does not mean the combination is without considerations
In its trial, participants lost about 19 percent of their body weight over 72 weeks, close to what tirzepatide delivers
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