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This reaction is called a thiol-disulfide exchange reaction

Originally developed for diabetes, GLP-1 agonists like semaglutide (Ozempic/Wegovy) and liraglutide have become popular GLP-1s for weight management because they help patients significantly reduce body weight by curbing appetite and calorie intake

These effects typically resolve with consistent use

Mild GI symptoms are common with weight loss drugs but typically ease as your body gets used to the medication

Diarrhea affects 15-23% of patients and may range from mild loose stools to frequent watery bowel movements

For these measurements, EC1 was used (ESM Table 2)